TRANSLATE NEXT GENERATION IMMUNE MODULATING ANTIBODIES INTO NEW THERAPEUTIC OPTIONS FOR PATIENTS
ImCheck Therapeutics is a Marseille-based, privately-held company developing next generation immuno-modulatory antibodies acting on both adaptive and innate immunity (notably gamma-delta T-cells) for the treatment of cancer and other immune related diseases.
With a “precision medicine-based” translational approach and several established academic collaborations, ImCheck is uniquely positioned to develop the right therapy for each patient.
To-date, ImCheck is developing two first-in-class therapeutic antibodies with a plan to enter into clinical trials by 2019. Imcheck is also advancing additional discovery programs on undisclosed targets.
Spin-off from Marseille’s Institut Paoli-Calmettes (IPC), one of the leading cancer center in Europe, ImCheck was founded in 2015 around discoveries of Professor Daniel Olive, a pioneer in innate immunity & co-signaling molecules and head of the immune monitoring program for early stage clinical trials in oncology at IPC.
OUR TRANSLATIONAL RESEARCH
The comprehensive bench-to-bedside research environment offered by the Marseille Cancer Research Center, the Paoli-Calmettes Cancer Institute, and Marseille Immunopole provides favorable conditions for our team to conduct discovery & clinical research in the field of immunotherapy. We will continue to actively explore and monitor patients’ immune response with the goal to develop molecules with strong impact on co-signaling pathways controlling adaptive and innate immune cells and overcome the resistance to currently available treatments.
Pr. Daniel Olive, MD, PhD, Founder & senior scientific advisor of ImCheck Therapeutics
Head of the Immunity and Cancer Department - Cancer Research Center of Marseille, France.
EXTEND THE BENEFITS OF IMMUNOTHERAPY
The concept of mobilizing the patient’s immune system to fight cancer has been known and studied for decades. The field turned a corner in 2011 when the FDA first approved the use of Immune Checkpoint Inhibitors, a new generation of cancer immunotherapy.
Immune Checkpoints refer to the multiple molecular signaling pathways modulating the duration and the amplitude of the immune response to prevent collateral tissue damage. Over the course of the disease, cancer cells usually exploit these checkpoints to evade recognition by immune cells and thus, avoid anti-tumor immunity.
Immune checkpoints are triggered by interaction between receptors and ligands (the molecules that bind to theses receptors), and can be modulated by antibodies to restore the ability of certain white blood cells to detect and kill tumors (or to decrease their hyperactivity in autoimmunity).
MORE PATIENTS - UNTREATED CANCERS - OTHER IMMUNE RELATED DISEASES
Checkpoint-blocking antibodies targeting inhibitory receptors (Immune Checkpoints Inhibitors) on T cells such as anti-CTLA-4 and anti-PD-1 have demonstrated clinical activity across a variety of solid and hematological tumors. However patients response rate remains relatively low, highlighting the importance of developing next generation treatments and new combinations.
To overcome resistance and improve patients’ outcome, ImCheck is developing a unique & proprietary portfolio of next generation immune modulators.
Clinical trials with Immunotherapies have proven that appropriate predictive models and biomarkers are critical for patient selection. Thus, ImCheck is implementing new translational R&D approaches combining predictive biomarkers development, experimental models based on freshly isolated human tumor samples and long established partnerships with a network of world class scientists.