ImCheck Therapeutics is designing and developing novel immunotherapeutics that target members of the butyrophilin (BTN) and BTN-like (BTNL) superfamily of checkpoint molecules with an initial focus on gamma delta (γ9δ2) T cells. ImCheck’s understanding of these novel targets benefits from the continued involvement of company scientific founder Prof. Daniel Olive (INSERM, CNRS, Institut Paoli Calmettes, Aix-Marseille University), a world-renowned researcher in γ9δ2T cells and BTNs, which has led to identification of additional immune cell populations that can be modulated through BTN(L)s, including tumor associated macrophages (TAMs).
ImCheck’s expertise in antibody-based drug discovery and translational research have enabled us to advance our first immuno-oncology program targeting BTN3A to activate γ9δ2T cells into the clinic in 2020 and to produce a broad pipeline of monoclonal antibody drug candidates.
Due to their mechanism of action, including the ability to simultaneously modulate innate and adaptive immunity, ImCheck's “first-in-class" antibodies may be able to improve upon the first-generation of checkpoint inhibitors in cancer. ImCheck’s programs also have potential in autoimmune and infectious disease indications, which the company is currently investigating.