ImCheck Therapeutics announced today it will present positive interim results from its ongoing open-label, randomized Phase I/II study EVICTION at the 66th American Society of Hematology (ASH) Annual Meeting. The poster presentation will provide data on the novel γ9δ2 T-cell activator, ICT01, in combination with azacitidine and venetoclax for the treatment of newly diagnosed acute myeloid leukemia (AML) in older and/or unfit patients. ICT01 is a first-in-class anti-butyrophilin 3A monoclonal antibody designed to activate γ9δ2 T cells among other immune cell classes. Data to be presented at ASH demonstrate that ICT01, both at the low and high dose levels, was safe and very well tolerated, and generated high rates of complete remission (CR) and composite CR across different molecular subgroups, particularly in TP53-mutated AML, a population with an especially poor prognosis (link to the abstract on the ASH 2024 website).
Details of the poster presentation are:
Abstract title: “The novel γ9δ2 T-cell activator ICT01 combined with azacitidine-venetoclax shows high rates of complete remission in older/unfit adults with newly diagnosed acute myeloid leukemia: interim results from Phase 1 study EVICTION”
Session: 616. Acute Myeloid Leukemias: Investigational Drug and Cellular Therapies: Poster II
Abstract number: 2876
Presenter: Abhishek Maiti, University of Texas MD Anderson Cancer Center
Authors: Abhishek Maiti, Pierre Yves Dumas, Pierre Peterlin, Daniel Morillo, Jose Torregrosa, Paul B. Koller, Maelle Mairesse, Patrick Brune, Emmanuel Valenitn, Aude De Gassart, Katrien Lemmens, Daniel Olive, Naval Daver, Stephan Braun, and Sylvain Garciaz.
Date: Sunday, Dec. 8, 2024
Time: 6:00-8:00 pm
Location: Halls G-H (San Diego Convention Center)
The ASH poster will be available on ImCheck’s corporate website after the poster sessions have been opened.