EVICTION trial proceeds to Phase IIa based on promising Phase I patient data for ICT01 across a broad range of solid tumors
ImCheck Therapeutics announced today that the first patients have been dosed in the Phase IIa monotherapy expansion arm in the ongoing Phase I/IIa EVICTION clinical trial of ICT01, a γ9δ2 T cell-activating monoclonal antibody targeting BTN3A. ImCheck will test two dose levels of ICT01 in patients with 2nd and 3rd line ovarian cancer or head and neck squamous cell carcinoma in the initial expansion arms.
ImCheck has presented results from Phase I of the EVICTION trial in oral presentations at major medical conferences in 2021, including AACR, ESMO and SITC, demonstrating ICT01’s safety, its powerful mechanism of action leading to activation, migration and tumor infiltration of circulating g9d2 T cells, CD8 T cells & NK cells, and initial tumor responses.
“We continue to meet our clinical development milestones and build on the positive clinical results we have reported to date. This is thanks to the great collaboration between the ImCheck team and an outstanding group of clinicians at trial centers in Europe and in the U.S.,” commented Pierre d’Epenoux, Chief Executive Officer of ImCheck Therapeutics. “ImCheck has now transitioned into a mid-stage clinical company which speaks to our commitment to developing new therapeutic options for cancer patients. As the most clinically-advanced company in the field of antibody therapies activating gamma-delta T cells, we aim to set a strong precedent for the development of innovative treatments in this area.”
Additional expansion arms are planned in hematological malignancies and in combination with pembrolizumab in solid tumor indications later this year.